????????? ???????? ?? ?? ??? ?? ????????? ??? ??????????????? ????????????? ????? ???????? ??? ???? ?? ???????? ???? ?????.Tadalafil is 14-fold much more potent for PDE5 than for PDE11A1 and forty-fold extra strong for PDE5 than for PDE11A4, two with the four known varieties of PDE11. PDE11 is an enzyme located in human prostate, testes, skeletal m